Ovarian Club X and CoGEN in Asia

SpeakerS

Inmaculada MORENO (Spain)

She was graduated in Biochemical Sciences in 2002 and obtained her European PhD in 2007 in Molecular microbiology, which was awarded the best PhD thesis. During her postdoctoral training she specialized on Molecular Oncology and then in Regenerative Medicine. From 2014 is a researcher at the R&D department of Igenomix where she is currently the research manager. From 2015 she collaborates at the Reproductive and Stem Cell Biology lab at Stanford University School of Medicine, where she is a Visiting Scholar from 2016. She is the author of more than 20 international publications in peer-review journals and has participated in several international projects.

Abstract

Implantation – Genomics to Microbiomics

The recent technological advances in next generation sequencing have facilitated the study of the bacterial structure and composition of low biomass microbiomes of tissues and organs that had been historically believed to be sterile, as the uterine cavity. Using this approach, the endometrial microbiota has been investigated, showing that similar to that on the vagina, the uterine microbiome is commonly made of Lactobacillus species. However, non-Lactobacillus dominated microbiome profile is associated with implantation failure, pregnancy loss, as well as other gynaecological and obstetrical conditions, adding a novel microbiological dimension to the reproductive process. This talk will focus on the current knowledge of the endometrial microbiome and the importance of assessing the endometrial microbiome as a future tool for improving reproductive outcomes in infertile patients.